Nausea and Vomiting Reduction

Cannabis-based medications, such as dronabinol and nabilone, have been found to significantly reduce chemotherapy-induced nausea and vomiting in cancer patients.

One notable study examining the efficacy of medicinal cannabis in treating vomiting and nausea is a systematic review and meta-analysis published in the British Journal of Pharmacology in 2001.

This review analysed data from 30 randomized controlled trials involving over 1,300 participants to evaluate the effectiveness of cannabinoids in managing chemotherapy-induced nausea and vomiting (CINV).

Here are some key findings from the study:

Reduction in Nausea and Vomiting

The meta-analysis found that cannabinoids, particularly delta-9-tetrahydrocannabinol (THC) and its synthetic analogs, were associated with a significant reduction in nausea and vomiting compared to placebo in patients undergoing chemotherapy.

Controlled Release Formulations

Controlled release formulations of THC, such as dronabinol and nabilone, were found to be more effective than conventional antiemetic medications (e.g., ondansetron, prochlorperazine) in preventing and controlling CINV. Dose-Dependent Response: The effectiveness of cannabinoids in reducing CINV appeared to be dose-dependent, with higher doses associated with greater symptom relief. However, higher doses also increased the risk of adverse effects, such as sedation, dizziness, and cognitive impairment.

Adverse Effects

While cannabinoids were generally well-tolerated, their use was associated with a higher incidence of adverse effects compared to placebo, including psychoactive effects, dry mouth, dizziness, and dysphoria. However, serious adverse events were rare.